CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Induction of hepatic fibrosis by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6
DOI 10.1055/s-0032-1331921
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Autor:innenE Hintermann, J Ehser, M Bayer, J Pfeilschifter, U Christen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Autoimmune hepatitis is an autoimmune liver disease whose cause is currently unknown. We recently developed an animal model which resembles AIH in that antigen-specific B – and T cell responses were observed. To trigger the disease an adenovirus (Ad) encoding the human Cytochrome P450IID6 (hCYP2D6), the major autoantigen in AIH type 2, was used. Importantly, infection with Ad-2D6 initiated autoimmune processes which…
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Zitierempfehlung
E Hintermann, J Ehser, M Bayer, J Pfeilschifter, U Christen (2013) Induction of hepatic fibrosis by an adenovirus encoding the human liver autoantigen cytochrome P450 2D6. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1331921
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