CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Establishment of a human in vitro model to investigate inflammatory immune reactions between Kupffer cell activation and hepatocyte damage – an approach to study DILI
DOI 10.1055/s-0032-1331924
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Nachweis in CareLit
Autor:innenV Kegel, T Schulz, B Burkhardt, A Haase, S Zellmer, A Luch, D Seehofer, M Glanemann, A Nüssler, G Damm
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hepatic tissue damage can occur due to surgical interventions, infections or drug induced liver injury (DILI). Kupffer cells (KC) play an important role in initiating tissue damage but also in regenerative processes. KC activation by LPS, foreign proteins or endogenous proteins can lead to an activation of the NF-κB signaling pathway mediated by reactive oxygen intermediates (ROI). Once activated, KCs release differ…
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Zitierempfehlung
V Kegel, T Schulz, B Burkhardt, A Haase, S Zellmer, A Luch, D Seehofer, M Glanemann, A Nüssler, G Damm (2013) Establishment of a human in vitro model to investigate inflammatory immune reactions between Kupffer cell activation and hepatocyte damage – an approach to study DILI. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1331924
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