CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A single quantitative trait locus on mouse chromosome 11 modifies in vitro hepatocyte susceptibility to TGF-β and in vivo fibrogenesis following CCl4 injections
DOI 10.1055/s-0032-1331930
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Autor:innenR Liebe, R Hall, S Dooley, F Lammert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: Hepatocyte damage triggers the release of cytokines and chemokines, thus initiating wound healing and immune cell recruitment. TGF-β is the central pro-fibrogenic cytokine, and exerts autocrine effects on neighbouring hepatocytes as well as attracting and activating myofibroblasts and macrophages. We speculated that genetic factors causing differenzial sensitivity of hepatocytes to TGF-β signalling may p…
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Zitierempfehlung
R Liebe, R Hall, S Dooley, F Lammert (2013) A single quantitative trait locus on mouse chromosome 11 modifies in vitro hepatocyte susceptibility to TGF-β and in vivo fibrogenesis following CCl4 injections. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1331930
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