CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Novel findings in an old model: Overexpression of c-myc in hepatocytes promotes the activation of hepatic stellate cells and facilitates the onset of liver fibrosis
DOI 10.1055/s-0032-1331935
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Nachweis in CareLit
Autor:innenYA Nevzorova, W Hu, U Haas, J Freimuth, F Tacke, C Trautwein, C Liedtke
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Aims: Overexpression of the proto-oncogene c-myc is frequently found in human and murine hepatocellular carcinoma. In mice, transgenic overexpression of c-myc in hepatocytes alb-myctg is sufficient to initiate liver cancer. However, the impact of c-myc for initiation of pathological precursor stages such as liver fibrosis is less defined. Liver fibrogenesis involves cell proliferation of hepatic cell…
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Zitierempfehlung
YA Nevzorova, W Hu, U Haas, J Freimuth, F Tacke, C Trautwein, C Liedtke (2013) Novel findings in an old model: Overexpression of c-myc in hepatocytes promotes the activation of hepatic stellate cells and facilitates the onset of liver fibrosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1331935
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