CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
α5β1 integrins act as sensors for tauroursodeoxycholic acid in hepatocytes
DOI 10.1055/s-0032-1331963
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Autor:innenA Sommerfeld, H Gohlke, R Reinehr, D Häussinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Ursodeoxycholic acid, which in vivo is converted to its taurine conjugate tauroursodeoxycholic acid (TUDC), is a mainstay for the treatment of cholestatic liver disease. Earlier work showed that TUDC exerts its choleretic properties in the perfused rat liver in a α5β1 integrin-mediated way (Häussinger et al., Gastroenterology, 2003). However, the molecular basis of TUDC-sensing in the liver is unknown.…
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Zitierempfehlung
A Sommerfeld, H Gohlke, R Reinehr, D Häussinger (2013) α5β1 integrins act as sensors for tauroursodeoxycholic acid in hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1331963
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