CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepcidin knockout mice develop chronic liver injury and liver fibrosis as a consequence of lysosomal iron overload
DOI 10.1055/s-0032-1331981
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Autor:innenM Lunova, S Vaulont, J Haybaeck, K Lackner, C Trautwein, P Strnad
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background and Aims: Hepcidin is the central regulator of iron homeostasis. Disrupted hepcidin signaling results in hereditary hemochromatosis and iron overload seen in chronic liver disorders. While the association between iron overload and development of end-stage liver disease is well established, the understanding of the underlying mechanisms is hampered by the lack of a suitable animal model. To circumvent this…
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Zitierempfehlung
M Lunova, S Vaulont, J Haybaeck, K Lackner, C Trautwein, P Strnad (2013) Hepcidin knockout mice develop chronic liver injury and liver fibrosis as a consequence of lysosomal iron overload. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1331981
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