CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Distinct Roles for Chk2/p53/p21 pathway in Liver Injury and Hepatocarcinogenesis
DOI 10.1055/s-0032-1332051
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Autor:innenLE Buitrago-Molina, S Marhenke, T Longerich, AE Boukouris, R Geffers, B Guigas, MP Manns, A Vogel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background and aims: Hepatocellular carcinoma (HCC) frequently arises in the context of chronic injury promoting DNA damage and chromosomal aberrations. Our aim was to further de-lineate the role of Chk2, p53 and p21 during acute and chronic liver injury and HCC initiation and progression. Methods: Mice with a targeted genetic deletion of Chk2, p53 or p21 were crossed into a murine model of human disease hereditary…
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Zitierempfehlung
LE Buitrago-Molina, S Marhenke, T Longerich, AE Boukouris, R Geffers, B Guigas, MP Manns, A Vogel (2013) Distinct Roles for Chk2/p53/p21 pathway in Liver Injury and Hepatocarcinogenesis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332051
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