CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Complete inhibition of mTORC1 cascade is required to suppress hepatocarcinogenesis induced by AKT and Ras co-expression
DOI 10.1055/s-0032-1332052
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Nachweis in CareLit
Autor:innenDF Calvisi, C Wang, B Fan, L Jiang, A Cigliano, S Delogu, F Dombrowski, X Chen, M Evert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: AKT and Ras pathways are frequently concurrently hyperactivated in HCC. Previously, we have shown that co-expression of constitutively active forms of AKT (Myr-AKT) and activated Ras (N-RasV12) rapidly induces liver tumors in mice. mTORC1 is the main downstream effector of AKT, acting by phosphorylation of RPS-6 and 4E-BP1, and thus regulating cell metabolism, protein translation and other cellular pro…
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Zitierempfehlung
DF Calvisi, C Wang, B Fan, L Jiang, A Cigliano, S Delogu, F Dombrowski, X Chen, M Evert (2013) Complete inhibition of mTORC1 cascade is required to suppress hepatocarcinogenesis induced by AKT and Ras co-expression. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332052
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