CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Akt/Notch activation drives rapid cholangiocarcinoma development originating from mature hepatocytes in the mouse
DOI 10.1055/s-0032-1332061
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Evert, B Fan, Y Malato, S Ribback, F Dombrowski, H Willenbring, X Chen, DF Calvisi
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Intrahepatic cholangiocarcinomas (ICCs) are primary liver tumors with a dismal prognosis. Activated AKT/mTOR pathway promotes both HCC and ICC development in the mouse liver. Notch signaling is known to play a critical role during bile duct development. Here we hypothesized that activated Notch signaling converted AKT-overexpressing preneoplastic hepatocytes into ICC in vivo. Methods: Activated Notch (…
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Zitierempfehlung
M Evert, B Fan, Y Malato, S Ribback, F Dombrowski, H Willenbring, X Chen, DF Calvisi (2013) Akt/Notch activation drives rapid cholangiocarcinoma development originating from mature hepatocytes in the mouse. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332061
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