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Transductional Targeting of oncolytic adenoviruses by adapter molecules improves therapy of pSia-expressing tumors by triggering adaptive immune responses
DOI 10.1055/s-0032-1332074
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Autor:innenA Kloos, E Gürlevik, N Woller, N Armbrecht, MP Manns, R Gerardy-Schahn, S Kubicka, F Kühnel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Polysialic acid (polySia) represents an excellent tumor-selective target for oncolytic adenovirus-based therapies since it is selectively expressed on several malignant tumors including small cell lung cancer (SCLC). In this study, we developed a strategy to retarget oncolytic Adenoviruses (OAV) to polySia-expressing tumors using a recombinant bispecific adapter protein. To generate the adapter molecule CARsc-pSia,…
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Zitierempfehlung
A Kloos, E Gürlevik, N Woller, N Armbrecht, MP Manns, R Gerardy-Schahn, S Kubicka, F Kühnel (2013) Transductional Targeting of oncolytic adenoviruses by adapter molecules improves therapy of pSia-expressing tumors by triggering adaptive immune responses. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332074
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