CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Active Ras signaling is involved in the transcriptional upregulation of the functional p53 inhibitor MDM4 in human and murine hepatocellular carcinoma
DOI 10.1055/s-0032-1332088
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Pellegrino, DF Calvisi, X Chen, M Evert, F Dombrowski, P Schirmacher, T Longerich
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
MDM4 is a p53 binding protein that negatively regulates p53-dependent transcription. MDM4 was found overexpressed in a variety of human cancers and amplifications of the MDM4 gene locus were reported with high frequency in most of the tumors analyzed. We have previously demonstrated that MDM4 is upregulated in about 50% of human hepatocellular carcinomas (HCC), both at messenger RNA and protein level. Although we id…
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Zitierempfehlung
R Pellegrino, DF Calvisi, X Chen, M Evert, F Dombrowski, P Schirmacher, T Longerich (2013) Active Ras signaling is involved in the transcriptional upregulation of the functional p53 inhibitor MDM4 in human and murine hepatocellular carcinoma. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332088
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