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HCC development is supported by proteasomal degradation of the tumor suppressor PML

K Straub, F Simon, K Khairzada, A Beilfuss, G Gerken, A Canbay, A Paul, F Weber, K Herzer · Zeitschrift für Gastroenterologie · Ausgabe 01/2013

DOI 10.1055/s-0032-1332099

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Autor:innenK Straub, F Simon, K Khairzada, A Beilfuss, G Gerken, A Canbay, A Paul, F Weber, K Herzer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Background: Hepatocellular carcinoma (HCC), which accounts for 80%-90% of primary liver tumors, is characterised by a very poor prognosis and is associated with high mortality. The molecular mechanisms responsible for development of this tumor are only incompletely understood. We could previously show that the promyelocytic leukaemia (PML) protein, a nuclear phosphoprotein which has been shown to inhibit cell growth…

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K Straub, F Simon, K Khairzada, A Beilfuss, G Gerken, A Canbay, A Paul, F Weber, K Herzer (2013) HCC development is supported by proteasomal degradation of the tumor suppressor PML. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332099

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