CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatocytes mediate Notch dependent immune regulation in response to inflammation in the regenerating mouse liver
DOI 10.1055/s-0032-1332120
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Autor:innenS Burghardt, A Erhardt, G Tiegs
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objective: A single injection of concanavalin A (ConA) to mice induces acute Th1-mediated hepatitis. Tolerance against ConA rechallenge develops within 8 days and is mediated by IL-10 predominantly produced by CD4+CD25+Foxp3+ regulatory T cells (Tregs) and Kupffer Cells. This study was intended to identify the role of hepatocytes (HC) in ConA-induced immunoregulation. Methods: HC or splenic DC were isolated from sal…
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Zitierempfehlung
S Burghardt, A Erhardt, G Tiegs (2013) Hepatocytes mediate Notch dependent immune regulation in response to inflammation in the regenerating mouse liver. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332120
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