CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Opposite role for the chemokines CCL5 (RANTES) and CXCL3 (IP-10) in the development of autoimmune liver disease in the CYP2D6 mouse model
DOI 10.1055/s-0032-1332128
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Nachweis in CareLit
Autor:innenJ Ehser, E Hintermann, M Bayer, J Pfeilschifter, U Christen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
The etiology of autoimmune hepatitis (AIH) is poorly understood although the major autoantigen, cytochrome P450 2D6 (CYP2D6), has been identified and immunodominant epitopes mapped. We generated a mouse model for AIH using the natural human autoantigen CYP2D6 as a triggering molecule. Wildtype C57BL/6 mice are infected with an adenovirus expressing the human CYP2D6 (Ad-2D6) in order to break self-tolerance to the mo…
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Zitierempfehlung
J Ehser, E Hintermann, M Bayer, J Pfeilschifter, U Christen (2013) Opposite role for the chemokines CCL5 (RANTES) and CXCL3 (IP-10) in the development of autoimmune liver disease in the CYP2D6 mouse model. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332128
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