CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Viral infection increases mitochondrial vulnerability and enhances TNF-induced apoptosis in hepatocytes
DOI 10.1055/s-0032-1332132
Bibliografische Angaben
Nachweis in CareLit
Autor:innenMK Frings, H Kashkar, M Krönke, M Heikenwälder, D Wohlleber, PA Knolle
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
TNFR ligation can induce two diverse signalling events: Survival via NFkB signalling, or apoptosis, involving generation of ROS and caspase activation. The mechanisms that control this decision are still not completely understood. We identified viral infection to induce a deadly outcome of TNFR-signalling: In a novel CD8+ T-cell effector mechanism secreted TNF induces selective clearance of infected hepatocytes, whe…
Zitieren
Zitierempfehlung
MK Frings, H Kashkar, M Krönke, M Heikenwälder, D Wohlleber, PA Knolle (2013) Viral infection increases mitochondrial vulnerability and enhances TNF-induced apoptosis in hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332132
Mit CareLit weiterarbeiten