CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
HLA-B*27 subtype specificity determines the targeting of HLA-B*27 restricted HCV-specific CD8+ T cell epitopes
DOI 10.1055/s-0032-1332166
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Autor:innenK Nitschke, J Schmidt, HE Blum, R Thimme, C Neumann-Haefelin
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
The HLA class I allele B*27 is associated with spontaneous viral clearance in Hepatitis C virus (HCV) genotype 1 infection. This protective effect of HLA-B*27 is linked to an immunodominant epitope as well as a subdominant epitope, both located in the HCV polymerase NS5B. Viral escape mutations occur consistently in these two epitopes in chronically infected patients and can abolish recognition of these epitopes by…
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Zitierempfehlung
K Nitschke, J Schmidt, HE Blum, R Thimme, C Neumann-Haefelin (2013) HLA-B*27 subtype specificity determines the targeting of HLA-B*27 restricted HCV-specific CD8+ T cell epitopes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332166
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