CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
CD8+ T cell escape of HCV by selection of a polymorphism in the epitope flanking region that impairs antigen processing and presentation
DOI 10.1055/s-0032-1332185
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Autor:innenA Walker, K Skibbe, S Groten, V Lüger, M Ruhl, T Kuntzen, TM Allen, J Timm
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Antiviral CD8+ T cells are a key component of the adaptive immune response against HCV, however, mutational escape by the virus in dominant epitopes contributes to viral persistence. Highly conserved immunodominant epitopes with a high genetic barrier to mutational escape are therefore attractive candidates for T cell based vaccines. The HLA-B*51-restricted CD8+ T cell epitope IPFYGKAI1373–1380 is highly…
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Zitierempfehlung
A Walker, K Skibbe, S Groten, V Lüger, M Ruhl, T Kuntzen, TM Allen, J Timm (2013) CD8+ T cell escape of HCV by selection of a polymorphism in the epitope flanking region that impairs antigen processing and presentation. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0032-1332185
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