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The role of ATP and purinergic-receptor-signalling in the pathogenesis of ALI/ARDS

S Cicko, T Müller, K Ayata, A Zech, K Baudiß, M Grimm, A Meyer, M Braun, S Sorichter, M Idzko · Pneumologie · Ausgabe 02/2013

DOI 10.1055/s-0033-1334718

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Autor:innenS Cicko, T Müller, K Ayata, A Zech, K Baudiß, M Grimm, A Meyer, M Braun, S Sorichter, M Idzko
ZeitschriftPneumologie
Ausgabe02/2013
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Background: Extracellular ATP serves as a danger signal to alert the immune system after tissue damage by acting on P2X or P2Y receptors. Acute lung injury (ALI)/acute respiratory syndrome (ARDS) is characterized by rapid alveolar injury, inflammation, cytokine production, neutrophils accumulation and vascular leakage leading to lung oedema. While recent data point out to an important role of ATP/P2R-axis in chronic…

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S Cicko, T Müller, K Ayata, A Zech, K Baudiß, M Grimm, A Meyer, M Braun, S Sorichter, M Idzko (2013) The role of ATP and purinergic-receptor-signalling in the pathogenesis of ALI/ARDS. Pneumologie (02). https://doi.org/10.1055/s-0033-1334718

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