CareLit · DOI-Nachweis · Pneumologie
A potential role of the proteoglycan biglycan in a murine model of allergic airway inflammation
DOI 10.1055/s-0033-1334719
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Autor:innenA Zech, T Müller, S Cicko, K Baudiß, K Ayata, M Braun, A Meyer, M Idzko
ZeitschriftPneumologie
Ausgabe02/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: The extracellular matrix component biglycan (Bgn), a small leucine-rich proteoglycan (SLRP), is known to act as damage-associated pattern (DAMP). Following secretion by activated macrophages or proteolytic digestion the soluble biglycan is capable of binding to TLR2, TLR4 and P2X7 thereby triggering downstream signalling events leading to an increased production of pro-inflammatory cytokines like IL-1ß,…
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Zitierempfehlung
A Zech, T Müller, S Cicko, K Baudiß, K Ayata, M Braun, A Meyer, M Idzko (2013) A potential role of the proteoglycan biglycan in a murine model of allergic airway inflammation. Pneumologie (02). https://doi.org/10.1055/s-0033-1334719
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