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Alternative and Classic Activation of Primary Human Macrophages – A Systems Biology Approach

W Bertrams, A Marsico, C Schulz, I Du Bois, A Sittka, M Vingron, N Suttorp, S Hippenstiel, B Schmeck · Pneumologie · Ausgabe 02/2013

DOI 10.1055/s-0033-1334756

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Autor:innenW Bertrams, A Marsico, C Schulz, I Du Bois, A Sittka, M Vingron, N Suttorp, S Hippenstiel, B Schmeck
ZeitschriftPneumologie
Ausgabe02/2013
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Macrophages are central players in lung pathology, having both regulatory and effector properties. Besides activation toward the M1 subtype, referred to as classic activation, alternatively activated M2 macrophages have been implicated in pneumonia, sarcoidosis, and malignoma. The molecular background of this phenotypic polarization is poorly understood. Recently, microRNAs (miRNA) have emerged as a regulatory netwo…

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W Bertrams, A Marsico, C Schulz, I Du Bois, A Sittka, M Vingron, N Suttorp, S Hippenstiel, B Schmeck (2013) Alternative and Classic Activation of Primary Human Macrophages – A Systems Biology Approach. Pneumologie (02). https://doi.org/10.1055/s-0033-1334756

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