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Different effects of glucose and potassium depolarization on the granule mobility in the submembrane space of insulin-secreting MIN6 cells

K Schumacher, M Matz, K Baumann, I Rustenbeck · Diabetologie und Stoffwechsel · Ausgabe 04/2013

DOI 10.1055/s-0033-1341689

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Autor:innenK Schumacher, M Matz, K Baumann, I Rustenbeck
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2013
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Background and aims: Physiologically, insulin secretion is initiated by an increase in the ambient glucose concentration. This involves a depolarization of the plasma membrane which is experimentally often mimicked by raising the K+ concentration in the medium. It has come into doubt, however, whether the stimulatory effect of a strong K+ depolarization, which produces a first phase-like insulin secretion, is based…

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K Schumacher, M Matz, K Baumann, I Rustenbeck (2013) Different effects of glucose and potassium depolarization on the granule mobility in the submembrane space of insulin-secreting MIN6 cells. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0033-1341689

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