CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Membrane potential-independent effect of Diazoxide on insulin secretion
DOI 10.1055/s-0033-1341691
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Willenborg, M Belz, A Hamada, I Rustenbeck
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: Glucose-induced insulin secretion is mediated by a bifurcating pathway generating “triggering” and “amplifying” signals. The standard protocol to demonstrate the amplifying effect of glucose (and other nutrient secretagogues) is to depolarize the beta cells by raising the external K+ concentration while the KATP channels are clamped open by Diazoxide to ensure the generation of the Nernst equili…
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Zitierempfehlung
M Willenborg, M Belz, A Hamada, I Rustenbeck (2013) Membrane potential-independent effect of Diazoxide on insulin secretion. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0033-1341691
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