CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Oleate rescues INS-1E β-cells from palmitate-induced ER-stress through a reduced phosphorylation of eIF2α
DOI 10.1055/s-0033-1341762
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Sommerweiss, T Gorski, S Laue, S Schuster, A Garten, W Kiess
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Free fatty acids (FFAs) are elevated in hyperlipidaemia which is a common pathology in obese individuals and often associated with diabetes. Therefore, FFAs, whose secretion from adipose tissue is increased in obesity, have been suggested to link obesity and type 2 diabetes. Saturated FFAs, such as palmitate, cause β-cell apoptosis which could be mediated through persistent endoplasmic reticulum (ER)-stress wh…
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Zitierempfehlung
D Sommerweiss, T Gorski, S Laue, S Schuster, A Garten, W Kiess (2013) Oleate rescues INS-1E β-cells from palmitate-induced ER-stress through a reduced phosphorylation of eIF2α. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0033-1341762
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