CareLit · DOI-Nachweis · Klinische Pädiatrie
Hematopoietic-specific lyn-substrate 1 (HCLS) is deacetylated by NAMPT/NAD+/SIRT1 pathway
DOI 10.1055/s-0033-1343621
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Nachweis in CareLit
Autor:innenB Samareh, K Welte, J Skokowa
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Recently we identified HCLS1 protein to be an essential player in the G-CSFR signalling pathway in myeloid differentiation (Skokowa et al., 2012). We also described a new G-CSFR signalling through activation of Nicotinamide phosphoribosyltransferase (NAMPT)/NAD+/Sirtuins in healthy individuals and in CN patients. We found that G-CSF-triggered deacetylation of myeloid specific factors is essential for myeloid differe…
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Zitierempfehlung
B Samareh, K Welte, J Skokowa (2013) Hematopoietic-specific lyn-substrate 1 (HCLS) is deacetylated by NAMPT/NAD+/SIRT1 pathway. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343621
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