CareLit · DOI-Nachweis · Klinische Pädiatrie
MiR-181a/b and -c/d act as tumor suppressors in MLL-rearranged leukemia by targeting the MLL-complex
DOI 10.1055/s-0033-1343622
Bibliografische Angaben
Nachweis in CareLit
Autor:innenF Dasci, S Emmrich, K Henke, J Kuipers, M Heuvel vd, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Mixed lineage leukemia (MLL) translocations are found in over 70% of infant leukemia. The wildtype MLL gene is involved in chromatin modification by methylating histone H3 (H3K4) and is crucial for leukemogenesis by interacting with the MLL-fusion proteins. MiR-181 was one of the first miRNAs described in the hematopoietic system and is repressed in MLL-rearranged AML. Here we show that forced expression of miR-181a…
Zitieren
Zitierempfehlung
F Dasci, S Emmrich, K Henke, J Kuipers, M Heuvel vd, JH Klusmann (2013) MiR-181a/b and -c/d act as tumor suppressors in MLL-rearranged leukemia by targeting the MLL-complex. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343622
Mit CareLit weiterarbeiten