CareLit · DOI-Nachweis · Klinische Pädiatrie
Characterization of oncogenes on chromosome 21 identified by shRNA-based viability screening
DOI 10.1055/s-0033-1343627
Bibliografische Angaben
Nachweis in CareLit
Autor:innenL Stachorski, VR Thangapandi, D Reinhardt, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Children with trisomy 21 (Down syndrome, DS) are predisposed to develop acute megakaryoblastic leukemia (DS-AMKL). Hypothesizing that the presence of an extra copy of human chromosome 21 (hsa21) is a basal requirement for the onset of DS-AMKL, we conducted a shRNA-based viability screening. We identified 26 oncogenic candidates genes on hsa21 conferring a profound growth disadvantage in DS-AMKL cell lines upon knock…
Zitieren
Zitierempfehlung
L Stachorski, VR Thangapandi, D Reinhardt, JH Klusmann (2013) Characterization of oncogenes on chromosome 21 identified by shRNA-based viability screening. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343627
Mit CareLit weiterarbeiten