CareLit · DOI-Nachweis · Klinische Pädiatrie
Continuous but not intermittent long-term exposure to the tyrosine kinase inhibitor (TKI) dasatinib causes cardiac failure in juvenile rats
DOI 10.1055/s-0033-1343629
Bibliografische Angaben
Nachweis in CareLit
Autor:innenP Geidel, JT Tauer, N Steinbronn, R Jung, E Bonifacio, I Leuschner, RH Strasser, M Suttorp
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
* these authors contributed equally to the work Background: TKI treatment can result in cardiac failure as these drugs exert off-target effects via so far ill-defined mechanisms. Long-term exposure is of great concern in pediatric patients which may require life-long treatment for diseases like chronic myeloid leukemia. We here investigated the impact of prolonged dasatinib exposure on the growing heart in juvenile…
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Zitierempfehlung
P Geidel, JT Tauer, N Steinbronn, R Jung, E Bonifacio, I Leuschner, RH Strasser, M Suttorp (2013) Continuous but not intermittent long-term exposure to the tyrosine kinase inhibitor (TKI) dasatinib causes cardiac failure in juvenile rats. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343629
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