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Identification of germline polymorphisms associated with clinical and toxicity phenotypes in childhood acute lymphoblastic leukemia

T Bartram, E Ellinghaus, R Houlston, M Zimmermann, A Möricke, G Cario, A Franke, M Schrappe, M Stanulla · Klinische Pädiatrie · Ausgabe 05/2013

DOI 10.1055/s-0033-1343635

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Autor:innenT Bartram, E Ellinghaus, R Houlston, M Zimmermann, A Möricke, G Cario, A Franke, M Schrappe, M Stanulla
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Background: There are many known undesirable side effects during childhood acute lymphoblastic leukemia (ALL) therapy. However, the reasons why some patients suffer from toxicities and others do not remains to be elucidated. Methods: Genome-wide association analyses of 1,048,683 single nucleotide polymorphisms (SNPs) were conducted in 1489 childhood ALL patients treated on protocol ALL-BFM 2000. Several variables in…

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T Bartram, E Ellinghaus, R Houlston, M Zimmermann, A Möricke, G Cario, A Franke, M Schrappe, M Stanulla (2013) Identification of germline polymorphisms associated with clinical and toxicity phenotypes in childhood acute lymphoblastic leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343635

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