CareLit · DOI-Nachweis · Klinische Pädiatrie
Finding the molecular basis for developmental-stage specific differences in hematopoietic stem and progenitor cells
DOI 10.1055/s-0033-1343636
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Nachweis in CareLit
Autor:innenT Dertmann, A Maroz, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
While the mutation of GATA1 (GATA1 s) has no phenotypic effect on adult hematopoietic stem and progenitor cells (HSPCs) it perturbs fetal hematopoiesis causing – on the background of trisomy 21 – transient leukemia (DS-TL) in neonates. The aim of this project is to elucidate the genetic background responsible for the sensitivity of fetal HSPCs towards GATA1-mutation. From gene array data, we chose genes with known i…
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Zitierempfehlung
T Dertmann, A Maroz, JH Klusmann (2013) Finding the molecular basis for developmental-stage specific differences in hematopoietic stem and progenitor cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343636
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