CareLit · DOI-Nachweis · Klinische Pädiatrie
Functional characterization of somatically mutated genes in neuroblastoma
DOI 10.1055/s-0033-1343641
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Krämer, S Ackermann, F Roels, H Kocak, F Hertwig, Y Kahlert, A Engesser, F Sherkheli, M Peifer, R Thomas, M Fischer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
To identify driver mutations in high risk neuroblastoma, whole-exome sequencing of 26 primary high risk neuroblastoma tumours was performed. Overall, a low mutation rate was observed in comparison to adult cancers. Few genes were recurrently mutated, indicating a substantial genomic heterogeneity of this tumour entity. In some tumours bearing MYCN amplification, driver mutations were identified in additional bona fi…
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Zitierempfehlung
A Krämer, S Ackermann, F Roels, H Kocak, F Hertwig, Y Kahlert, A Engesser, F Sherkheli, M Peifer, R Thomas, M Fischer (2013) Functional characterization of somatically mutated genes in neuroblastoma. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343641
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