CareLit · DOI-Nachweis · Klinische Pädiatrie
Selective inhibition of Histone Deacetylase 8 as a novel therapeutic strategy for the treatment of high-risk neuroblastoma
DOI 10.1055/s-0033-1343645
Bibliografische Angaben
Nachweis in CareLit
Autor:innenI Wiegand, T Milde, HE Deubzer, S Balasubramanian, O Witt, I Oehme
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Expression studies of primary neuroblastoma samples from the German Neuroblastoma Trial revealed histone deacetylase 8 (HDAC8) to be upregulated in stage 4 patients, associated with a significantly worse prognosis. Here, we investigated the anti-neuroblastoma activity of HDAC8-selective inhibitors (HDAC8i) in vitro and in vivo. Methods: Treatment of neuroblastoma cell lines and mouse xenografts were used to ev…
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Zitierempfehlung
I Wiegand, T Milde, HE Deubzer, S Balasubramanian, O Witt, I Oehme (2013) Selective inhibition of Histone Deacetylase 8 as a novel therapeutic strategy for the treatment of high-risk neuroblastoma. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343645
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