CareLit · DOI-Nachweis · Klinische Pädiatrie
Molecular stratification of medulloblastoma: Comparison of histological and genetical methods to detect Wnt activated tumors
DOI 10.1055/s-0033-1343649
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Autor:innenT Goschzik, A zur Mühlen, G Kristiansen, T Pietsch
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In a cohort of 188 pediatric medulloblastomas our aim was to identify the optimal methods in standard clinical practice to detect those with Wnt activation, which is associated with good outcome. Therefore, nuclear accumulation of ß-Catenin was analyzed by immunohistochemistry (IHC) using 3 different automated staining systems. Also SSCP (single-strand conformation polymorphism) analysis and direct Sanger sequencing…
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Zitierempfehlung
T Goschzik, A zur Mühlen, G Kristiansen, T Pietsch (2013) Molecular stratification of medulloblastoma: Comparison of histological and genetical methods to detect Wnt activated tumors. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343649
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