CareLit · DOI-Nachweis · Klinische Pädiatrie
Acetylation of LEF-1 transcription factor regulating hematopoietic differentiation
DOI 10.1055/s-0033-1343651
Bibliografische Angaben
Nachweis in CareLit
Autor:innenI Kuznetsova, M Ünalan, K Welte, J Skokowa
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Previously we identified that NAMPT is essential for the G-CSF-triggered granulocytic differentiation via a NAD+- sirtuin-1-dependent pathway. Sirtuins are NAD+-dependent protein deacetylases and we found that myeloid-specific transcription factors C/EBPα and C/EBPß are deacetylated and activated by SIRT1. We and others demonstrated, that lymphoid enhancer-binding factor 1 (LEF-1) transcription factor is crucial for…
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Zitierempfehlung
I Kuznetsova, M Ünalan, K Welte, J Skokowa (2013) Acetylation of LEF-1 transcription factor regulating hematopoietic differentiation. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343651
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