CareLit · DOI-Nachweis · Klinische Pädiatrie
An alternative splice process renders MLL either into an transcriptional activator or repressor
DOI 10.1055/s-0033-1343653
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Nachweis in CareLit
Autor:innenT Rössler, T Dingermann, R Marschalek
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We analyzed the biological properties of the MLL PHD1 – 3 domain. This domain is encoded by MLL exons 11 – 16 and localizes next to the Bromo-domain (MLL exons 17 – 19). We have identified 4 different splice variants that alter functions of the PHD domain 3, in particular its dimerization capacity and binding to CYP33 or H3K4me3. Binding to CYP33 allows to complex with BMI1, CBX4, HDAC and KDM 5B, and thus, to repre…
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Zitierempfehlung
T Rössler, T Dingermann, R Marschalek (2013) An alternative splice process renders MLL either into an transcriptional activator or repressor. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343653
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