CareLit · DOI-Nachweis · Klinische Pädiatrie
Genotyping of KIR/KIRL mismatch, FCGR2A, -3A and -3B polymorphisms in patients subject to high-risk neuroblastoma immunotherapy using melting curve analysis
DOI 10.1055/s-0033-1343654
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Jensen, N Siebert, HN Lode
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Immunotherapy with anti-GD2 monoclonal antibody (mAB) ch14.18 prolongs survival of patients with high-risk neuroblastoma (NB). Since clinical response to some mAbs is associated with immunoglobulin-like receptor (KIR)/KIR-ligand (KIRL) mismatch and Fcγ-receptor (FCGR) polymorphisms, we established a Real-Time-PCR (qPCR) analysis of KIR, FCGR2A (H131R), -3A (V158F) and -3B (NA1/NA2) polymorphisms. Metho…
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Zitierempfehlung
C Jensen, N Siebert, HN Lode (2013) Genotyping of KIR/KIRL mismatch, FCGR2A, -3A and -3B polymorphisms in patients subject to high-risk neuroblastoma immunotherapy using melting curve analysis. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343654
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