CareLit · DOI-Nachweis · Klinische Pädiatrie
Fenretinide (4-HPR) as immunostimulator of the antibody-dependent (ADCC) and antibody-independent NK cell mediated cytotoxicity (AICC) on neuroblastoma
DOI 10.1055/s-0033-1343658
Bibliografische Angaben
Nachweis in CareLit
Autor:innenI Lichy, A Stermann, D Seidel, N Siebert, HN Lode
ZeitschriftKlinische Pädiatrie
Ausgabe05/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: A current approach to consolidate remissions in the treatment of neuroblastoma (NB) consists of an anti-GD2-directed immunotherapy plus cytokines in combination with 13-cis retinoic acid. Fenretinide (4-HPR) is a synthetic derivative of retinoic acid and it is in clinical development for the treatment of high-risk NB patients. Since 4-HPR induces apoptosis mainly via the accumulation of ceramides, whic…
Zitieren
Zitierempfehlung
I Lichy, A Stermann, D Seidel, N Siebert, HN Lode (2013) Fenretinide (4-HPR) as immunostimulator of the antibody-dependent (ADCC) and antibody-independent NK cell mediated cytotoxicity (AICC) on neuroblastoma. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0033-1343658
Mit CareLit weiterarbeiten