CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Therapeutic application of activated Protein C epigenetically constrains the redox-enzyme p66shc in diabetic nephropathy
DOI 10.1055/s-0033-1347766
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Autor:innenF Bock, K Shahzad, H Wang, R Ritzel, V Schwenger, T Madhusudhan, C Esmon, P Nawroth, B Isermann
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Mice with genetically increased levels of activated Protein C (aPC) are protected against diabetic nephropathy and have decreased glomerular expression levels of the mitochondrial-targeted redox enzyme p66shc. In mice therapeutic application of aPC ameliorates indices of diabetic nephropathy and podocyte damage. The therapeutic mechanism and how intermittent application of a plasma protein with a half…
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Zitierempfehlung
F Bock, K Shahzad, H Wang, R Ritzel, V Schwenger, T Madhusudhan, C Esmon, P Nawroth, B Isermann (2013) Therapeutic application of activated Protein C epigenetically constrains the redox-enzyme p66shc in diabetic nephropathy. Diabetologie und Stoffwechsel (08). https://doi.org/10.1055/s-0033-1347766
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