CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Dual inhibition of Notch and JAK/STAT impairs pancreatic cancer progression in vitro and in vivo and is superior to monotherapies
DOI 10.1055/s-0033-1352689
Bibliografische Angaben
Nachweis in CareLit
Autor:innenV Palagani, P Bozko, M El Khatib, H Belahmer, B Sipos, N Malek, R Plentz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high rate of metastasis. Recent studies have indicated that Notch and JAK2/STAT3 signaling pathways are both important for the initiation and progression of PDAC. The purpose of this study was to determine the outcome of targeting these two tumor signaling pathways simultaneously both in vitro and in vivo. Methods: We assess…
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Zitierempfehlung
V Palagani, P Bozko, M El Khatib, H Belahmer, B Sipos, N Malek, R Plentz (2013) Dual inhibition of Notch and JAK/STAT impairs pancreatic cancer progression in vitro and in vivo and is superior to monotherapies. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0033-1352689
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