CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Role of Pyruvate kinase M2 (PKM2) in tumor growth, cancer cell migration and tumor angiogenesis
DOI 10.1055/s-0033-1352695
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Autor:innenN Azoitei, G Rehbein, F Genze, S Brobovich, M Armacki, K Fiedler, T Seufferlein
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: The pyruvate kinase isoforms PKM1 and PKM2 are alternatively spliced products of the pkm2 gene. PKM2, but not PKM1, is expressed in highly proliferating cells such as embryonic cells and all cancer cells reported to date. PKM2 has been reported to alter glucose metabolism in cancer cells and to contribute to tumorigenesis by mechanisms that are not explained by its known biochemical activity. Aim: The…
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Zitierempfehlung
N Azoitei, G Rehbein, F Genze, S Brobovich, M Armacki, K Fiedler, T Seufferlein (2013) Role of Pyruvate kinase M2 (PKM2) in tumor growth, cancer cell migration and tumor angiogenesis. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0033-1352695
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