CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The multikinase inhibitor sorafenib induces p53 family-dependent apoptosis in hepatocellular carcinoma
DOI 10.1055/s-0033-1352723
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Brost, AL Thomas, C Quack, H Bantel, CS Falk, M Müller
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The multikinase inhibitor sorafenib represents the first medical therapy to prolong survival of patients suffering from hepatocellular carcinoma. Here, we propose a new model of action for sorafenib via accumulation and activation of p53 and its family members p63 and p73. We have previously linked the p53 family to hepatocarcinogenesis, chemosensitivity and prognosis in hepatocellular carcinoma. Here, we show that…
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Zitierempfehlung
S Brost, AL Thomas, C Quack, H Bantel, CS Falk, M Müller (2013) The multikinase inhibitor sorafenib induces p53 family-dependent apoptosis in hepatocellular carcinoma. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0033-1352723
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