CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Role of methylthioadenosine phosphorylase (MTAP) in hepatic stellate cell activation
DOI 10.1055/s-0033-1352779
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Autor:innenB Czech, D Valletta, K Dettmer, M Müller, A Bosserhoff, P Oefner, C Hellerbrand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The activation of hepatic stellate cells (HSCs) is a key event of hepatic fibrosis, and the polyamine metabolic pathway has been implicated to affects hepatic fibrosis. Methylthioadenosine phosphorylase (MTAP) the rate-limiting enzyme in the methionine and adenine salvage pathway catalyzes the phosphorylation of 5'-deoxy-5′-(methylthio)adenosine (MTA), which is a by-product of polyamine synthesis. The aim of this st…
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Zitierempfehlung
B Czech, D Valletta, K Dettmer, M Müller, A Bosserhoff, P Oefner, C Hellerbrand (2013) Role of methylthioadenosine phosphorylase (MTAP) in hepatic stellate cell activation. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0033-1352779
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