CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Intrahepatic bile acid retention in BALB/c-Abcb4-/--mice activates FXR-dependent rescue transporters at the basolateral and canalicular membrane
DOI 10.1055/s-0033-1352781
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Pasupuleti, A Geier, Y Churin, M Roderfeld, E Roeb
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by progressive obliteration of bile ducts, accumulation of bile acids and secondary biliary fibrosis. Abcb4 involves the transport of phospholipids from hepatocytes into bile across the canalicular membrane. Abcb4 knockout disturbes the excretion of phospholipids into bile leading to a more toxic bile composition and bile duct…
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Zitierempfehlung
S Pasupuleti, A Geier, Y Churin, M Roderfeld, E Roeb (2013) Intrahepatic bile acid retention in BALB/c-Abcb4-/--mice activates FXR-dependent rescue transporters at the basolateral and canalicular membrane. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0033-1352781
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