CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The frequent PNPLA3 risk variant p.I148 M is associated with decreased pruritus in cholestasis: novel role of a prosteatotic polymorphism
DOI 10.1055/s-0033-1352796
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Autor:innenM Krawczyk, E Wunsch, F Grünhage, V Zimmer, M Milkiewicz, P Milkiewicz, F Lammert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and aims: The common PNPLA3 (adiponutrin) variant p.I148 M is associated with severe forms of liver diseases1. Of note, the minor allele [M] at this locus promotes the conversion of lysophosphatidic acid (LPA) into phosphatidic acid (PA)2, resulting in increased cellular diacylglycerol synthesis. Since LPA functions as a mediator of cholestatic pruritus3, we now investigate the effects of the PNPLA3 varia…
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Zitierempfehlung
M Krawczyk, E Wunsch, F Grünhage, V Zimmer, M Milkiewicz, P Milkiewicz, F Lammert (2013) The frequent PNPLA3 risk variant p.I148 M is associated with decreased pruritus in cholestasis: novel role of a prosteatotic polymorphism. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0033-1352796
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