CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A cell autonomous EGFR-NFATc1 loop promotes acinar to ductal metaplasia in pancreatic carcinogenesis
DOI 10.1055/s-0033-1352847
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Autor:innenG Singh, N Chen, L Regul, E Glesel, S Baumgart, SK Singh, A König, K Reutlinger, B Geisel, TM Gress, V Ellenrieder
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2013
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Recent evidence has shown a crucial role for EGFR activation in KrasG12 D -driven pancreatic carcinogenesis. However, the key transcription pathways conferring EGFR signalling in early tumorigenesis are enigmatic. Aims: To define signaling networks in EGFR driven ADM formation in vitro and in vivo. Methods: KrasG12 D mice strains with pancreas specific differential NFATc1 activation were challenged by…
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Zitierempfehlung
G Singh, N Chen, L Regul, E Glesel, S Baumgart, SK Singh, A König, K Reutlinger, B Geisel, TM Gress, V Ellenrieder (2013) A cell autonomous EGFR-NFATc1 loop promotes acinar to ductal metaplasia in pancreatic carcinogenesis. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0033-1352847
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