CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeting H3.3 mutated pediatric high grade gliomas – A high throughput screening approach to identify novel therapeutic agents
DOI 10.1055/s-0033-1353460
Bibliografische Angaben
Nachweis in CareLit
Autor:innenPD Johann, D Sturm, T Milde, S Bender, S Stark, H Seker-Cin, N Truffaux, J Grill, O Witt, AE Kulozik, P Lichter, J Lewis, S Pfister
ZeitschriftKlinische Pädiatrie
Ausgabe11/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Pediatric high grade gliomas (pHGG) are among the most common malignant brain tumors in childhood and account for the majority of cancer related mortality in this age group. The recent discovery of two recurrent mutations in the tail of histone variant H3.3, resulting either in a substitution of Glycine at position 34 (G34R/V) or Lysine at position 27 (K27 M), has deepened our understanding of this tumor entity and…
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Zitierempfehlung
PD Johann, D Sturm, T Milde, S Bender, S Stark, H Seker-Cin, N Truffaux, J Grill, O Witt, AE Kulozik, P Lichter, J Lewis, S Pfister (2013) Targeting H3.3 mutated pediatric high grade gliomas – A high throughput screening approach to identify novel therapeutic agents. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0033-1353460
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