CareLit · DOI-Nachweis · Klinische Pädiatrie
Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma
DOI 10.1055/s-0033-1353461
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Tchoghandjian, C Jennewein, I Eckhardt, K Rajalingam, S Fulda
ZeitschriftKlinische Pädiatrie
Ausgabe11/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Since inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the Smac mimetic BV6, which antagonizes IAP proteins, on non-apoptotic functions in glioblastoma (GBM). Here, we identify non-canonical NF-κB signaling and a TNFα/TNFR1 autocrine/paracrine loop as critical mediators of BV6-stimulated migration and invasion of GBM cells. In addition,…
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Zitierempfehlung
A Tchoghandjian, C Jennewein, I Eckhardt, K Rajalingam, S Fulda (2013) Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0033-1353461
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