CareLit · DOI-Nachweis · Klinische Pädiatrie
Temozolomide induced autophagy stimulates senescence and inhibits apoptosis in glioma cells
DOI 10.1055/s-0033-1353464
Bibliografische Angaben
Nachweis in CareLit
Autor:innenAV Knizhnik, WP Roos, T Nikolova, B Kaina
ZeitschriftKlinische Pädiatrie
Ausgabe11/2013
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Autophagy is a process induced by nutrient limitation and cellular stress, which governs degradation of long-lived proteins and whole organelles, thereby maintaining a balance between synthesis, degradation and recycling of cellular components. Alkylating agents, in particular temozolomide (TMZ), are used as first line chemotherapy of gliomas. TMZ induces several DNA adducts, among which O6-methylguanine (O6MeG) is…
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Zitierempfehlung
AV Knizhnik, WP Roos, T Nikolova, B Kaina (2013) Temozolomide induced autophagy stimulates senescence and inhibits apoptosis in glioma cells. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0033-1353464
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