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Molecular mechanisms of EGFR activation by carbon nanoparticles in lung epithelial cells

D Stöckmann, H Peuschel, U Sydlik, M Kroker, N Ale-Agha, S Jakob, J Haendeler, S Grether-Beck, K Unfried · Pneumologie · Ausgabe 12/2013

DOI 10.1055/s-0033-1357059

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Autor:innenD Stöckmann, H Peuschel, U Sydlik, M Kroker, N Ale-Agha, S Jakob, J Haendeler, S Grether-Beck, K Unfried
ZeitschriftPneumologie
Ausgabe12/2013
Jahrgang / SeitenNicht angegeben

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Background: Particulate air pollution induces pathogenic endpoints like proliferation, apoptosis, and pro-inflammatory reactions in lung epithelial cells. The activation of the epidermal growth factor receptor (EGFR) is a key step responsible for signaling events specific for these endpoints. Earlier experiments identified particle-derived reactive oxygen species (ROS) as one possible trigger eliciting the observed…

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D Stöckmann, H Peuschel, U Sydlik, M Kroker, N Ale-Agha, S Jakob, J Haendeler, S Grether-Beck, K Unfried (2013) Molecular mechanisms of EGFR activation by carbon nanoparticles in lung epithelial cells. Pneumologie (12). https://doi.org/10.1055/s-0033-1357059

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