CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Antifibrotic effects of CCN1/CYR61 in primary portal myofibroblasts through induction of reactive oxygen species and resulting apoptosis
DOI 10.1055/s-0033-1360842
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Autor:innenE Borkham-Kamphorst, C Schaffrath, E van de Leur, U Haas, L Tihaa, SK Meurer, R Weiskirchen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Cysteine-rich protein 61 (CCN1/CYR61) is a matricellular protein of the CCN family that comprises six secreted CCN proteins in mammals [1, 2]. In adults, CCN1/CYR61 expression is associated with inflammation and injury repair. Recent studies showed that CCN1/CYR61 limits fibrosis in models of cutaneous wound healing by inducing cellular senescence in myofibroblasts of the granulation tissue which thereby transform i…
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Zitierempfehlung
E Borkham-Kamphorst, C Schaffrath, E van de Leur, U Haas, L Tihaa, SK Meurer, R Weiskirchen (2014) Antifibrotic effects of CCN1/CYR61 in primary portal myofibroblasts through induction of reactive oxygen species and resulting apoptosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360842
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