CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
An additional heme oxygenase-1 knockout increases systemic inflammation and fibrosis in MDR2 knockout mice
DOI 10.1055/s-0033-1360847
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Autor:innenR Barikbin, M Sandmann, A Quaas, G Tiegs, G Sass
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2014
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: Deletion of the multi drug resistance protein 2 (Mdr2) in mice causes hepatic inflammation and fibrosis with progression to hepatocellular carcinoma (HCC) at about 12 month of age (Mdr2 knockout mouse; Mdr2ko; FVB.129P2-Abcb4tm1Bor). We have recently shown that induction of heme oxygenase-1 (HO-1) in Mdr2ko mice interferes with liver inflammation, fibrosis formation and proliferation. We now established…
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Zitierempfehlung
R Barikbin, M Sandmann, A Quaas, G Tiegs, G Sass (2014) An additional heme oxygenase-1 knockout increases systemic inflammation and fibrosis in MDR2 knockout mice. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0033-1360847
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